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In vitro studies have shown that nucleoside reverse transcriptase inhibitors can decrease mitochondrial DNA content and complement-mediated phagocytosis in human monocyte-derived macrophages (120)

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Repeated minor strain is thought to be the major precipitating factor in tendinopathy, although further work is required to determine whether it is mechanical overstimulation or understimulation that leads to the change in tenocyte activity

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