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Most individuals find 0.1 to 0.15 mg daily sufficient for chronic condition management

MDPI PubMed Nature Claims of differential pro versus anti angiogenic activity derive primarily from animal corneal and tissue injury models and should not be extrapolated to tumor biology without human data

10.1007/s00018-025-05770-1 613 TsurutaH.NagamuraT.KimuraK.IgarashiY.KajitaA.WangZ

Most are not (Schedule IV or V or not scheduled at all), but they carry sedation risks and are generally recommended for short-term use only

A 2025 systematic review of orthopaedic applications screened hundreds of articles and found almost no human data