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NICE guidance on the assessment and management of overweight and obesity in adults (currently CG189 and associated updates) provides the overarching framework, alongside the technology appraisals for semaglutide 2

According to CareEdge Ratings, the GLP-1 market, valued at around 1,0001,200 crore in 2025, is expected to grow to 4,5005,000 crore by 2030, with patent expiry acting as a key driver

Previous studies have shown that chronic GCG receptor agonism increased circulating FGF21 in mice and acute glucagon administration transiently increased FGF21 levels in humans 25

Conclusion GLP-1 receptor agonists have fundamentally reshaped obesity treatment by enabling unprecedented pharmacological weight loss

Although long-acting GLP-1 receptor agonists commonly cause nausea, the side effect is typically short-lived, and patients generally tolerate the treatment well