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6.3 Patient population in the PIONEER program (PIONEER 18) Across the PIONEER program, the majority of patients were adults ( 18 years) with a diagnosis of T2D and baseline HbA 1c levels in the range of 7.09.5% [38, 39, 61, 62, 76,77,78,79,80,81,82]

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Several preclinical studies in animal models have suggested that GLP-1 receptor agonists may reduce nicotine-seeking behaviour and attenuate the rewarding effects of nicotine