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CYP7A1 is simultaneously inhibited by an FXR-small heterodimer partner (SHP), which is the downstream target of FXR in the liver, whereas FXR in enterocytes inhibits CYP7A1 activation in hepatocytes by secreting fibroblast growth factor 19 (FGF19) and binding to fibroblast growth factor receptor 4 (FGFR4) on the hepatocyte membrane (77)

Thus, there is little data from which to draw conclusions about its safety, especially regarding long-term use in humans [2]

CALIPER: a software for blood-free parametric Patlak mapping using PET/MRI input function